Weight Loss Procedures Without Gastric Surgery

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Weight loss is a complex process that often requires a combination of lifestyle changes, medications, and outpatient procedures. Bariatric (weight loss) surgeries are highly effective, but many people opt for other weight loss options due to the associated costs, commitment, and risks.

This article reviews weight loss outpatient procedures, reasons to consider bariatric surgery alternatives, insurance coverage, and nonsurgical weight loss support. 

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Weight Loss Outpatient Procedures and Interventions

Endoscopic weight loss procedures are minimally invasive outpatient interventions. Before the procedure, you will get medicine to make you sleepy. The healthcare provider uses an endoscope (a thin, flexible tube with a camera) to reach your stomach through your esophagus. Below are examples of standard endoscopic weight loss procedures and their pros and cons.

Intragastric Balloons

A healthcare provider places an intragastric balloon, like Orbera or Obalon, in your stomach and fills it with liquid or air to help you feel full sooner. 

Aspiration Therapy

AspireAssist is a type of aspiration therapy in which a healthcare provider places a tube in your stomach. The tube connects to a button that allows you to drain your stomach contents after meals, cutting calories by about 30%.

Bypass Liners 

A healthcare provider places bypass liners, like EndoBarriers, into your small intestine (the tube that carries food between your stomach and the large intestine). These liners create a barrier that reduces appetite and changes how you absorb calories.

Pros

  • Averages an 11% weight decrease 

  • Can reduce blood sugar, blood pressure, and cholesterol

  • Minimally invasive

Endoscopic Sleeve Gastroplasty (ESG) and Gastric Plication

An endoscopic sleeve gastroplasty (ESG) reduces stomach size by stitching and reshaping it into a tubular shape, making you feel full sooner. An ESG can reduce total body weight by 16% and excess weight by 60%. Gastric plication achieves a similar result by folding and stitching the stomach, creating wrinkles.

Pros

  • Gradual weight loss

  • No incision

  • Quick recovery

Endoscopic Gastric Bypass Revision

An endoscopic gastric bypass revision is an endoscopic procedure that modifies a previous gastric bypass without requiring additional major surgery.

Reasons to Consider Bariatric Surgery Alternatives 

The following bariatric surgeries can reduce excess weight by up to 75%. However, they require a lifelong commitment to dietary changes and can cause side effects like dumping syndrome (food moves too quickly from your stomach to small intestine). Types of bariatric surgery include:

Many people explore nonsurgical alternatives to reduce risk; some favor them for the following reasons: 

  • Broader eligibility
  • Convenience 
  • Fewer complications
  • Gradual weight loss 
  • Lower cost
  • Reversibility

Insurance Coverage for Weight Loss Procedures and Interventions 

Bariatric surgery costs between $15,000 and $25,000 without insurance.

Medicare, Medicaid, or private insurance companies often cover bariatric surgery if you meet certain requirements. If this is the case, surgery may be less expensive than endoscopy. However, with growing support for endoscopic effectiveness, insurance coverage and cost-effectiveness are increasing for these procedures. 

Comparing initial vs. long-term costs should also be considered. One study shows that endoscopic sleeve gastroplasty (ESG) costs more than Wegovy (semaglutide) in the first year, but after five years, ESG is much less expensive:

Timeline  ESG Wegovy (semaglutide)
First 12 months  $17,229 $11,742
After five years $19,685 (cumulative cost) $53,268

The manufacturer offers a coupon card program for Wegovy, costing some consumers nothing each month.

Nonsurgical Weight Loss Support and Resources 

Healthcare providers design medical weight loss programs to monitor progress, identify modifiable behavior, and recommend lifestyle changes, supplements, medications, injections, and special devices, or alternative care like acupuncture.

Supplements

Weight loss supplements containing African mango, green tea extract, carnitine, curcumin, and rhubarb might help you achieve your weight loss goals, but the evidence to support their use varies and isn’t always strong.

Supplement safety and effectiveness vary as well. Supplements could interact with the medicines you take, and some are costly or even dangerous. For example, for safety reasons, in 2004, the Food and Drug Administration (FDA) banned ephedra, a substance derived from an evergreen shrub that contains stimulant compounds, for safety reasons.

Talk to your healthcare team about the risks and benefits if you are considering supplements.

Weight Loss Programs

Some weight loss programs offer meal plans or prepackaged meals, calorie counting, portion control, and behavior modification. While these plans are convenient, some people avoid them due to restrictive rules, time commitments, and potentially high costs. 

Weight Loss Medications

The following weight loss medications affect how your body processes food or reduce your appetite: 

  • Alli, Xenical (orlistat)
  • Contrave (bupropion and naltrexone)
  • Qsymia (phentermine and topiramate) 

The following glucagon-like peptide (GLP) medications work by mimicking the body’s natural hormones. They can result in 15% to 20% weight loss. In the past, bariatric surgery was the only option for this range of weight loss. GLP drugs include:

Below are the pros and cons associated with weight loss medications.

Cons

  • May forget to take them 

  • Some require self-injection

  • May need to take them indefinitely

  • Not everyone qualifies 

  • Potential side effects

  • Some medications are costly

  • Uncertain long-term effects of newer medications

Injection Therapies

Your provider may recommend the following injections to help dissolve fat, boost metabolism, or curb appetite:

  • Vitamin B12
  • Lipolysis like Kybella (deoxycholic acid)
  • Lipotropic (amino acid) injections 
  • Peptides
Pros

  • Convenient

  • Rapid action

  • Target specific areas

Body Contouring or Sculpting

An esthetician, usually found in dermatology or plastic surgery clinics, specializes in body sculpting, which reshapes your body by reducing fat in certain areas. Techniques include:

Pros

  • Noninvasive

  • Low-risk

  • Quick

  • Limited downtime

Cons

  • Will not help with overall weight loss

  • May cause discomfort, swelling, bruising, or discoloration

  • Not typically covered by insurance (because it is cosmetic)

  • The average cost is $1,226 per session

  • Results may require repeat sessions

Summary 

Weight loss success often involves multiple methods. In addition to lifestyle changes or bariatric surgery, there are also nonsurgical methods. Medical weight loss teams may recommend behavioral therapy, supplements, weight loss medications, and nonsurgical interventions.

For example, endoscopic procedures are less invasive than surgery and have a minimal recovery time. However, it’s essential to check insurance coverage as many cover surgery but will not cover weight loss medications or endoscopic procedures.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Syn NL, Cummings DE, Wang LZ, et al. Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants. Lancet. 2021;397(10287):1830-1841. doi:10.1016/S0140-6736(21)00591-2

  2. Yoon JY, Arau RT. Study group for endoscopic bariatric and metabolic therapies of the Korean society of gastrointestinal endoscopy. the efficacy and safety of endoscopic sleeve gastroplasty as an alternative to laparoscopic sleeve gastrectomy. Clin Endosc. 2021;54(1):17-24. doi:10.5946/ce.2021.019

  3. Food and Drug Administration. FDA approves AspireAssist obesity device.

  4. Ryder REJ, Laubner K, Benes M, et al. Endoscopic duodenal-jejunal bypass liner treatment for type 2 diabetes and obesity: glycemic and cardiovascular disease risk factor improvements in 1,022 patients treated worldwide. Diabetes Care. 2023;46(4):e89-e91. doi:10.2337/dc22-1952

  5. Haseeb M, Chhatwal J, Xiao J, Jirapinyo P, Thompson CC. Semaglutide vs. endoscopic sleeve gastroplasty for weight loss. JAMA Netw Open. 2024;7(4):e246221. doi:10.1001/jamanetworkopen.2024.6221

  6. Nduma BN, Mofor KA, Tatang JT, Ekhator C, Ambe S, Fonkem E. Endoscopic gastric sleeve: a review of literature. Cureus. 2023;15(3):e36353. doi:10.7759/cureus.36353

  7. Clapp B, Ponce J, DeMaria E, et al. American Society for Metabolic and Bariatric Surgery 2020 estimate of metabolic and bariatric procedures performed in the United States. Surg Obes Relat Dis. 2022;18(9):1134-1140. doi:10.1016/j.soard.2022.06.284

  8. National Institute of Diabetes and Digestive and Kidney Diseases. Definition and facts of weight-loss surgery.

  9. Piłat P, Szpila G, Stojko M, Nocoń J, Smolarczyk J, Żmudka K, Moll M, Hawranek M. Modern and non-invasive methods of fat removal. Medicina (Kaunas). 2023;59(8):1378. doi:10.3390/medicina59081378

  10. National Institutes of Health Office of Dietary Supplements. Dietary supplements for weight loss.

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  12. Sarma S, Palcu P. Weight loss between glucagon-like peptide-1 receptor agonists and bariatric surgery in adults with obesity: a systematic review and meta-analysis. Obesity (Silver Spring). 2022;30(11):2111-2121. doi:10.1002/oby.23563

  13. American Society for Plastic Surgeons. What is non-surgical fat reduction?

  14. American Board of Cosmetic Surgery. Non-surgical fat reduction.

  15. American Society for Plastic Surgeons. Nonsurgical fat reduction minimally invasive procedures.

By Brandi Jones, MSN-ED RN-BC

Jones is a registered nurse and freelance health writer with more than two decades of healthcare experience.

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